High mobility group box1 protein is involved in acute inflammation induced byClostridium difficiletoxin A
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چکیده
منابع مشابه
High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A
High Mobility Group Box1 (HMGB1), a damage-associated inflammatory factor, plays an important role in the pathogenesis of numerous chronic inflammatory and autoimmune diseases. In this study, the role of the HMGB1 in TcdA-induced ER stress was identified. Clostridium difficile toxin A is one of the major virulence factors of C. difficile infection (CDI) and has been proved to induce apoptotic c...
متن کاملUp-regulation of TLR2 and TLR4 in high mobility group Box1-stimulated macrophages in pulpitis patients
Objective(s): High Mobility Group Box1 (HMGB1) is a nonhistone, DNA-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. The aim of this study was to explore whether HMGB1 stimulation can up-regulate the expression of Toll-like Receptor 2 (TLR2) and Toll-like Receptor 4 (TLR4) on macrophages from p...
متن کاملHigh mobility group box 1 protein as a late-acting mediator of acute lung inflammation.
Acute inflammatory lung injury is often a delayed complication of critical illness and is associated with increased mortality. High mobility group box 1 (HMGB1) protein, in addition to its role as a transcriptional regulator factor, has been identified as a late mediator of endotoxin lethality and might be also involved in the development and progression of acute lung injury. HMGB1 protein itse...
متن کاملup-regulation of tlr2 and tlr4 in high mobility group box1-stimulated macrophages in pulpitis patients
objective(s): high mobility group box1 (hmgb1) is a nonhistone, dna-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. the aim of this study was to explore whether hmgb1 stimulation can up-regulate the expression of toll-like receptor 2 (tlr2) and toll-like receptor 4 (tlr4) on macrophages from p...
متن کاملNeuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific researches emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low ...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2016
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmw038